2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154489
    5-Bromo-2’-deoxy-2’-fluoro-β-D-arabinouridine
    5-Bromo-2’-deoxy-2’-fluoro-β-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Bromo-2’-deoxy-2’-fluoro-β-D-arabinouridine
  • HY-152605
    2’-Deoxy-2’-fluoro-6-S-methyl-6-thio-arabino-inosine
    2’-Deoxy-2’-fluoro-6-S-methyl-6-thio-arabino-inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluoro-6-S-methyl-6-thio-arabino-inosine
  • HY-152728
    3’-Azido-3’-deoxycytidine
    3’-Azido-3’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-Azido-3’-deoxycytidine
  • HY-137651A
    Sp-2'-F-dATP-αS tetrasodium
    Sp-2'-F-dATP-αS tetrasodium is a dATP (HY-136648) derivative. Sp-2'-F-dATP-αS tetrasodium can be used in cancer research.
    Sp-2'-F-dATP-αS tetrasodium
  • HY-154723
    2’-Deoxy-2’-fluoro-N3-(4-hydroxybenzyl)uridine
    2’-Deoxy-2’-fluoro-N3-(4-hydroxybenzyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluoro-N3-(4-hydroxybenzyl)uridine
  • HY-W061531
    5-O-TBDPS-1,2-di-O-isopropy lidene-3-keto-alpha-D-xylofuranoside
    5-O-TBDPS-1,2-di-O-isopropy lidene-3-keto-alpha-D-xylofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-O-TBDPS-1,2-di-O-isopropy lidene-3-keto-alpha-D-xylofuranoside
  • HY-152306
    N1,N3-Bis(cyanomethyl)pseudouridine
    N1,N3-Bis(cyanomethyl)pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1,N3-Bis(cyanomethyl)pseudouridine
  • HY-152607
    N,N-Dimethyl-2′-O-methyladenosine
    N,N-Dimethyl-2′-O-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N,N-Dimethyl-2′-O-methyladenosine
  • HY-180697
    4-Oxo-4,5-dihydroimidazole-5-acetic acid
    4-Oxo-4,5-dihydroimidazole-5-acetic acid is a nucleoside metabolite.
    4-Oxo-4,5-dihydroimidazole-5-acetic acid
  • HY-154126
    2’,3’,5’-Tri-O-benzoyl-5-hydroxy methyluridine (see GL100342)
    2’,3’,5’-Tri-O-benzoyl-5-hydroxy methyluridine (see GL100342) is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    2’,3’,5’-Tri-O-benzoyl-5-hydroxy methyluridine (see GL100342)
  • HY-154475
    9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine
    9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine
  • HY-154565
    5’-Deoxy-5’-N,N-dimethylamino thymidine
    5’-Deoxy-5’-N,N-dimethylamino thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-Deoxy-5’-N,N-dimethylamino thymidine
  • HY-152319
    3’-Azido-3’-deoxy-N6,N6-dimethyladenosine
    3’-Azido-3’-deoxy-N6,N6-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-N6,N6-dimethyladenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-Azido-3’-deoxy-N6,N6-dimethyladenosine
  • HY-154116
    6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine
    6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine
  • HY-152342
    N1-Methoxymethyl pseudouridine
    N1-Methoxymethyl pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methoxymethyl pseudouridine
  • HY-180634
    CMP-2-Aminoethylphosphonate
    CMP-2-Aminoethylphosphonate is a nucleoside metabolite.
    CMP-2-Aminoethylphosphonate
  • HY-154395
    2-Chloro-2′-deoxy-N,N-dimethyladenosine
    2-Chloro-2′-deoxy-N,N-dimethyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Chloro-2′-deoxy-N,N-dimethyladenosine
  • HY-W377454
    1-Beta-D-arabinofuranosyl-5-iodouracil
    1-Beta-D-arabinofuranosyl-5-iodouracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-Beta-D-arabinofuranosyl-5-iodouracil
  • HY-49203
    2’-O-Acetyl-3,5-bis-O-(2,4-dichlorobenzyl)adenosine
    2’-O-Acetyl-3,5-bis-O-(2,4-dichlorobenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2’-O-Acetyl-3,5-bis-O-(2,4-dichlorobenzyl)adenosine
  • HY-180688
    (Z)-But-1-ene-1,2,4-tricarboxylate
    (Z)-But-1-ene-1,2,4-tricarboxylate (cis-Homoaconitate) is a nucleoside metabolite.
    (Z)-But-1-ene-1,2,4-tricarboxylate